Ipi Nivo combos- what's new? G. Long

Uveal Melanoma

58% OS Ipi/ Nivo at 3 years in skin Melanoma- highest ever survival in Melanoma

• primary resistance about 30%
• toxicity
• rarer subgroups of Melanoma

UM median OS 9- 12 months in stage 4

PD1 mono 

ORR 3.6% 

mPFS= 2.6 months

seems to have low PDL1 overall

GEM1402: Ipi + Nivo standard scheme in UM

ORR 11.5%

PFS 2.78 months

OS 56% at 1 year and very few patients at end of curve- so not trustworthy

overall disappointing :-(

IMCgp100- 102 

19 patients only

68% OS at 1 year

CHECKMATE 511

Nivo low plus Ipi         vs       Nivo plus Ipi low

endpoints: toxicity

not powered for ORR, PFS and OS    *sigh*

and let's pretend we're surprised: more Ipi is more toxic 

and there more discontinuations.....

really- hard to see what this trial was supposed to answer